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HPE Proliant DL380 Gen10 Xeon-S 4210R 10-core 32GB 8SFF P408i-A 800W 3-Year Part Code :P50751-B21


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  • Supports the latest Intel Xeon Scalable processors for up to 60% performance gain and 27% increase in cores

  • Up to 3.0 TB HPE DDR4 SmartMemory with optional Intel Optane persistent memory 100 series for HPE

  • Supports 12 Gb/s SAS and up to 20 NVMe drives

  • Wide range of compute options, including single or dual processors

  • Comprehensive security features, including locking bezel kit, intrusion detection kit, and HPE TPM 2.0

  • Accelerate demanding workloads with high performance and scalability

  • Improve efficiency and reduce costs with intelligent power management

  • Protect your data with advanced security features

  • Deploy with confidence with a comprehensive warranty and support


Adaptable for diverse workloads and environments, the secure 2P 2U HPE ProLiant DL380 Gen10 delivers world-class performance with the right balance of expandability and scalability. Designed for supreme versatility and resiliency while being backed by a comprehensive warranty make it ideal for multiple environments from Containers to Cloud to Big Data. Standardize on the industry's most trusted compute platform.

Identify your performance bottleneck and upgrade seamlessly with the HPE ProLiant DL380 Gen10 server.

This powerful server is designed to tackle any workload, whether you're limited by storage, processing power, or expansion capability. With the latest Intel Xeon processors and advanced memory technology, it delivers up to a 60% performance boost and supports massive storage expansion. Plus, its secure design and comprehensive warranty give you peace of mind.

Here's what makes the DL380 Gen10 stand out:

Handle demanding workloads with ease thanks to powerful processors and high-speed memory.

Scalability without limits: Grow your server as your needs evolve with flexible storage and expansion options.

Built-in security: Protect your data and infrastructure with advanced security features.

Simplified management: Manage your server effortlessly with HPE's intuitive tools and software.

Run everything you need with confidence - from basic applications to mission-critical tasks.

Key improvements:

Removed unnecessary promotional tone.

Focused on the reader's problem (bottleneck) and solution (upgrading).

Highlighted key features and benefits in a clear and concise way.

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  • Protect your applications and data proactively with the latest HPE Trusted Supply Chain solution, even before your server is assembled. 

  • This innovative offering now supports additional second-generation Intel® Xeon® Scalable processor family options. Moreover, it enhances Single-Width GPU Density, accommodating up to 7 NVIDIA Tesla T4 16GB Computational.

  • Accelerators or 7 Xilinx Alveo U50 Accelerators within a standard-depth 2U rack form factor. 

  • Additionally, our Networking Choice (NC) server models offer increased flexibility in selecting primary networking options.

Safeguarding Applications and Data Pre-Server Construction via HPE Trusted Supply Chain

Introducing a groundbreaking initial defense against cyber threats: exclusive servers constructed to meet the highest security standards in highly secured facilities. This comprehensive approach integrates cutting-edge security measures, meticulous processes, and expert personnel to ensure the safeguarding of your most sensitive applications and data right from the pre-assembly stage of your server.


Built in secure HPE facilities to the most stringent Country of Origin USA and conformance requirements, HPE Trusted Supply Chain servers are inspected to be free from malicious microcode and counterfeit parts, safeguarding it against cyber-exploits throughout its life cycle.


With hardened security built in, HPE Trusted Supply Chain hardens the protections designed into select HPE products with unrivaled supply chain visibility and standards compliance providing a 360-degree view and mitigation plan for current and emerging cyber-threats.

Adaptable Design: Scaling Your Investment Alongside Your Business Growth
  • The HPE ProLiant DL380 Gen10 server has an adaptable chassis, including new Hewlett Packard Enterprise modular drive bay configuration options with up to 30 SFF, up to 19 LFF or up to 20 NVMe drive options along with support for up to three double wide GPU options.

  • Adapting and growing to changing business needs, Networking Choice (NC) server models provide flexibility in the primary networking choice while Embedded LOM server models offer an embedded 4x1GbE by default; both provide network options (1GbE to 100GbE) via HPE FlexibleLOM or PCIe standup adapters.

  • HPE Persistent Memory works with DRAM to provide fast, high capacity, cost effective memory and storage to transform big data workloads and analytics by enabling data to be stored, moved, and processed quickly.

  • In conjunction with the embedded SATA HPE Dynamic Smart Array S100i Controller for boot, data and media needs, the redesigned HPE Smart Array Controllers allow you the flexibility to choose the optimal 12 Gb/s controller most suited to your environment, and operate in both SAS and HBA mode.

  • Supporting a wide range of operating environments from Azure to Docker to ClearOS in addition to traditional operating systems.

Top-Tier Services and Streamlined Deployment
  • The HPE ProLiant DL380 Gen10 server is bundled with a comprehensive suite of HPE Technology Services, offering assurance, mitigating risks, and enabling customers to achieve flexibility and reliability.

  • HPE Services streamlines every phase of the IT journey. Experts in Advisory and Transformation Services grasp customer hurdles and devise the most effective solutions. Professional Services facilitate swift implementation of solutions, while Operational Services deliver continual support.

  • A suite of embedded and downloadable tools is available for server lifecycle management including Unified Extensible Firmware Interface (UEFI), Intelligent Provisioning; HPE iLO 5 to monitor and manage; Smart Update Manager (SUM), and Service Pack for ProLiant (SPP).

  • Hewlett Packard Enterprise IT investment solutions help you transform to a digital business with IT economics that align to your business goals.

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